Endocrine Disease (Part III)

(Courtesy of Anna Meredith MA VetMB CertLAS DZooMed MRCVS
Royal [Dick] School of Veterinary Studies)

Endocrine Disorders in Ferrets:

Disease Clinical
Signs
Differential
Diagnosis
Diagnostic
Options
Treatment
Adrenal
Disease
Symmetric al
flank
alopecia,
swollen
vulva,
dysuria in
males.
Oestrus,
ovarian
remnant,
seasonal
alopecia
Haematolo
gy,
ultrasonog
raphy,
plasma
steroid
hormone
levels.
Surgical
removal,
mitotane at
50mg PO
daily for 7
days then
maintenanc
e of 50mg
every third
day, GnRH
agonist and
anti-sex
steroid
drugs.
Hyperoestrogeni
sm
Swollen
vulva,
weakness,
pale mucus
membranes,
petechiae,
ecchymoses,
systolic
murmur,
alopecia,
melaena.
Hyperadrenoc
orticism,
ovarian
remnant,
cardiac
disease,
trauma,
abdominal
neoplasia,
bone marrow
neoplasia,
chronic
disease.
History,
clinical
signs,
haematolo
gy
(particularl
y PCV)
Stabilisation,
Vitamin B,
iron,
prophylactic
antibiotics,
blood
transfusion,
HCG or
GnRH
injection,
ovariohyster
ectomy once
stabilised.
Insulinoma Collapse,
hypersalivati
on, glazed
eyes, ataxia,
weakness,
lethargy.
Starvation,
liver disease,
sepsis, cardiac
disease,
lymphoma,
anaemia,
trauma, spinal
disease, CNS
neoplasia,
toxins, Canine
Distemper
virus, Aleutian
disease.
History,
clinical
signs,
blood
glucose
levels,
blood
insulin
levels.
Surgical
partial
pancreatect
omy,
prednisolon
e 0.5
2mg/kg PO
BID with or
without
diazoxide 5
10mg/kg
PO BID.
Feed small
high protein
meals often.
Diabetes
mellitus
Polyuria,
polydypsia,
Glycosuria,
anorexia
Renal disease,
urolithiasis,
cystitis, GI
foreign body,
neoplasia,
dental disease,
cardiac
disease,
severe
metabolic
disease.
Persistent
glycosuria,
elevated
blood
glucose
levels.
Insulin
therapy if
not
associated
with recent
pancreatic
surgery.
Start on
0.1IU per
ferrets
subcutaneo
us injection
twice daily.
Spontaneou
s resolution
has been
reported
following
surgery for
insulinoma.

(First published in NFWS News - #85 September 2009)